Table 2.
HR for risk of outcomes according to quartiles of the baseline TyG index
| Variables | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P for trend |
|---|---|---|---|---|---|
| ASCVD events | 251 | 411 | 522 | 800 | |
| Incidence, per 1000 person-year | 1.48 (1.31–1.67) | 2.62 (2.38–2.88) | 3.49 (3.20–3.80) | 5.66 (5.28–6.06) | |
| Model 1 | Reference | 1.53 (1.30–1.78) | 1.85 (1.59–2.15) | 2.77 (2.40–3.20) | < 0.001 |
| Model 2 | Reference | 1.30 (1.11–1.52) | 1.34 (1.15–1.57) | 1.61 (1.38–1.89) | < 0.001 |
| MI | 29 | 57 | 87 | 139 | |
| Incidence, per 1000 person-year | 0.17 (0.12–0.24) | 0.36 (0.28–0.47) | 0.58 (0.47–0.71) | 0.97 (0.82–1.14) | |
| Model 1 | Reference | 1.83 (1.17–2.86) | 2.67 (1.75–4.07) | 4.12 (2.75–6.16) | < 0.001 |
| Model 2 | Reference | 1.57 (0.99–2.46) | 1.96 (1.27–3.01) | 2.46 (1.60–3.79) | < 0.001 |
| IS | 161 | 248 | 300 | 395 | |
| Incidence, per 1000 person-year | 0.95 (0.81–1.10) | 1.58 (1.39–1.78) | 1.20 (1.78–2.24) | 2.77 (2.51–3.06) | |
| Model 1 | Reference | 1.46 (1.20–1.78) | 1.71 (1.42–2.08) | 2.22 (1.85–2.67) | < 0.001 |
| Model 2 | Reference | 1.26 (1.03–1.54) | 1.26 (1.03–1.53) | 1.23 (1.01–1.51) | 0.281 |
| Revascularization therapy | 74 | 140 | 196 | 356 | |
| Incidence, per 1000 person-year | 0.43 (0.35–0.54) | 0.89 (0.75–1.05) | 1.30 (1.13–1.49) | 2.49 (2.24–2.76) | |
| Model 1 | Reference | 1.71 (1.29–2.27) | 2.24 (1.71–2.92) | 3.87 (3.01–4.98) | < 0.001 |
| Model 2 | Reference | 1.42 (1.07–1.89) | 1.58 (1.20–2.07) | 2.37 (1.81–3.10) | < 0.001 |
| All-cause mortality | 243 | 321 | 341 | 487 | |
| 1.42 (1.25–1.61) | 2.03 (1.82–2.26) | 2.25 (2.03–2.51) | 3.38 (3.09–3.70) | ||
| Model 1 | Reference | 1.25 (1.06–1.48) | 1.28 (1.09–1.52) | 1.79 (1.53–2.09) | < 0.001 |
| Model 2 | Reference | 1.18 (1.00-1.40) | 1.16 (0.98–1.38) | 1.39 (1.17–1.65) | 0.003 |
Model 1 was adjusted for age and sex
Model 2 was adjusted for age, sex, educational background, smoking status, drinking status, snoring, BMI, SBP, history of hypertension, history of diabetes mellitus, family history of CVD, use of antidiabetic agents, lipid-lowering agents, antihypertensive medications, TC, HDL-C, LDL and hs-CRP and the TyG index
ASCVD atherosclerotic cardiovascular disease, MI myocardial infarction, IS ischemic stroke, BMI body mass index, SBP systolic blood pressure, CVD cardiovascular disease, TC total cholesterol, HDL-C high density lipoproteincholesterol, LDL-C low density lipoproteincholesterol, hs-CRP high sensitivity C-reactive protein, TyG index triglyceride-glucose index