Table 4.
Subgroup analysis of the association between the TyG index and ASCVD events or all-cause mortality
| ASCVD events | All-cause mortality | |||||
|---|---|---|---|---|---|---|
| Variables | Adjusted HR (95% CI) | P-value | P for interaction | Adjusted HR (95% CI) | P-value | P for interaction |
| Sex | 0.105 | 0.115 | ||||
| Male | 1.44 (1.19–1.73) | 0.001 | 1.37 (1.12–1.67) | 0.002 | ||
| Female | 2.28 (1.70–3.06) | < 0.001 | 1.44 (1.02–2.02) | 0.038 | ||
| BMI | 0.087 | 0.010 | ||||
| < 28 | 1.63 (1.37–1.95) | 0.027 | 1.43 (1.18–1.73) | < 0.001 | ||
| ≥ 28 | 1.38 (0.98–1.95) | 0.065 | 1.50 (0.95–2.35) | 0.081 | ||
| Hypertension | 0.116 | 0.003 | ||||
| Yes | 1.76 (1.38–2.24) | < 0.001 | 1.11 (0.86–1.45) | 0.414 | ||
| No | 1.51 (1.22–1.86) | < 0.001 | 1.60 (1.27–2.01) | < 0.001 | ||
| Diabetes mellitus | 0.158 | 0.819 | ||||
| Yes | 3.13 (1.01–9.83) | 0.044 | 1.16 (0.47–2.87) | 0.747 | ||
| No | 1.45 (1.24–1.71) | < 0.001 | 1.32 (1.10–1.58) | 0.002 | ||
| Smoking | 0.042 | 0.677 | ||||
| Yes | 1.31 (1.02–1.67) | 0.033 | 1.52 (1.16–1.98) | 0.002 | ||
| No | 1.87 (1.53–2.29) | < 0.001 | 1.30 (1.03–1.62) | 0.281 | ||
| Drinking | 0.001 | 0.363 | ||||
| Yes | 1.25 (0.97–1.60) | 0.107 | 1.44 (1.09–1.88) | 0.009 | ||
| No | 1.91 (1.56–2.33) | < 0.001 | 1.34 (1.07–1.68) | 0.010 | ||
Model was adjusted for age, sex, educational background, smoking status, drinking status, snoring, SBP, history of hypertension, history of diabetes mellitus, family history of CVD, use of antidiabetic agents, lipid-lowering agents, antihypertensive medications, TC, HDL-C, LDL-C, hs-CRP and the TyG index
ASCVD atherosclerotic cardiovascular disease, BMI body mass index, SBP systolic blood pressure, CVD cardiovascular disease, TC total cholesterol, HDL-C high density lipoproteincholesterol, LDL-C low density lipoproteincholesterol, hs-CRP high sensitivity C-reactive protein, TyG index triglyceride-glucose index