Table 2.

Data transformation methods.

RAW	No transformation
Log2	$E=Lo{g}_2(e+1)$
Total	$E=\frac{e}{sum(e)}\ast 20000$
l2-norm	$E=\frac{e}{\sqrt{sum(e^2)}}$
Minmax	$E=\frac{e-min(e)}{max(e)-min(e)}$
Z-score	$E=\frac{e-mean(e)}{std(e)}$

Where e is a vector of gene expression level in a cell

We used six statistics to transform single-cell RNA sequencing data. These statistics are widely used in sequencing data analysis studies