Table 5.

Advantages/usages of microfluidic devices (BBB-on-a-chip models) in different areas

Areas	Advantages/usage
Physiological relevance	Tight connections between endothelial cells and the existence of transporters are two distinguishing characteristics of the BBB that BBB-on-a-Chip models accurately mimic62,66. Because of this physiological relevance, scientists/researchers may examine how medications interact with the barrier in a controlled setting, giving them information about whether they can pass the BBB67.
High throughput	Potential drug candidates can be screened in a high-throughput manner using these models. Multiple substances can be tested at once by researchers hastening the drug development process68.
Real-time monitoring	Drug transport and cellular responses can be observed in real-time using BBB-on-a-Chip technologies, hence, this dynamic examination offers insightful information on medication permeability and potential BBB side effect69–71.
Disease modelling	These models allow for the incorporation of disease-specific components, enabling researchers to examine drug delivery in the setting of neurological diseases like Alzheimer’s or glioblastoma. This aids in identifying prospective treatments and evaluating their effectiveness71–73.

BBB, blood-brain barrier.