Fig. 2.

nAChR subtypes in brain dopamine systems. (A) Ventral midbrain dopaminergic neurons that project to the dorsal striatum or nucleus accumbens are stimulated by nicotine, resulting in increased dopamine transmission in the striatum. (B) Major stoichiometries of nAChRs predicted to be expressed by dopaminergic and GABAergic neurons in the ventral tegmental area. (C) Major stoichiometries of nAChRs predicted to be expressed by on the terminals of dopaminergic in the dorsal striatum and nucleus accumbens.