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. 2022 Jan;74(1):271–310. doi: 10.1124/pharmrev.121.000299

Fig. 4.

Fig. 4

Organization and nAChR subtypes of the habenula-interpeduncular nucleus circuit. (A) Substance P–expressing neurons in in the dorsal region of the mHb and cholinergic neurons in the ventral mHb corelease glutamate and project to the IPn. The IPn send predominately GABAergic projections to the raphe nuclei, LDTg, and the nucleus incertus (NI). (B) Graphical representation of subregions of the interpeduncular nucleus, including the rostral, dorsolateral (DL), intermediate (I), and central (Cen) nuclei that receive input from cholinergic neurons in the ventral mHb. (C) Major stoichiometries of nAChRs predicted to be expressed presynaptically and postsynaptically in the mHb. (D) Major stoichiometries of nAChRs predicted to be expressed presynaptically and postsynaptically in the mHb in the IPn.