Extended Data Fig. 1 |. Disease and RHBDF expression.

(a) (left) Thoracic computed tomography (CT) scan in healthy control. (right) Photographs of the mucosa from lower G.I. endoscopy in healthy control. (b) RNA−seq data (GTEx Portal https://www.gtexportal.org) showing RHBDF2 expression across organs. (c) RHBDF1 expression in peripheral blood cell-types. Data are derived from the single cell RNA-seq dataset from the GEO database, accession number GSE149689. The clusters were projected into a 2-dimensional space using uniform manifold approximation and projection (UMAP) and identified using (left panel) canonical markers, and (right panel) RHBDF1 expression in individual cells. Color intensity indicates the expression level.