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. 2016 Jan;68(1):20–48. doi: 10.1124/pr.115.011502

Fig. 1.

Fig. 1.

Normal mitochondrial structure in the heart. (Left) Representative micrographs of section of the mouse left ventricle showing immunofluorescence staining for TCA cycle enzyme citrate synthase. The mitochondria appear as tiny green, bead-like structures (Alexa 488, green fluorescence). Nuclei are stained blue (DAPI; 4′,6-diamidino-2-phenylindole). Scale bar = 10 µm. (Middle) Isolated rat cardiomyocytes showing the intracellular mitochondrial network by confocal fluorescence microscopy stained with MitoTracker red. The cytoskeleton protein F-actin is green and the cell nucleus is blue (DAPI; 4′,6-diamidino-2-phenylindole). 600×. Scale bar = 0.4 µm. (Right) Electron micrograph of normal mouse heart mitochondria. Cardiomyocyte exhibits abundant electron-dense mitochondria (m) surrounded by smooth endoplasmic reticulum (SER). N = cell nucleus. Scale bar = 0.2 μm.