TABLE 5.
Cox Proportional Hazards Model of Transplantation or Death in Patients With Group 1 Pulmonary Arterial Hypertension
| Unadjusted | Adjusted for Age, Sex, BMI, and O2 Use | Adjusted for Age, Sex, BMI, Prescribed O2, and DlCO | |||||||
|---|---|---|---|---|---|---|---|---|---|
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| n | HR (95% CI) | P Value | n | HR (95% CI) | P Value | n | HR (95% CI) | P Value | |
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| AHI, 10 events/h increment | 185 | 0.94 (0.74–1.20) | 0.62 | 185 | 0.93 (0.70–1.23) | 0.60 | 182 | 1.01 (0.78–1.30) | 0.97 |
| Percentage of recording time at <90% SpO2, 10% increment | 180 | 1.12 (1.04–1.22) | 0.005 | 180 | 1.16 (1.06–1.27) | <0.001 | 177 | 1.17 (1.07–1.28) | <0.001 |
| Oxygen desaturation index (3%) by 10 events/h | 176 | 0.95 (0.79–1.16) | 0.63 | 176 | 1.04 (0.84–1.30) | 0.71 | 173 | 1.08 (0.88–1.33) | 0.47 |
| T90 >37% (median) vs ≤37% | 180 | 2.31 (1.19–4.46) | 0.013 | 180 | 2.31 (1.14–4.68) | 0.020 | 177 | 2.55 (1.25–5.21) | 0.010 |
| T90 by quartiles | 180 | 180 | 177 | ||||||
| >2.24%−37% vs 0%−2.24% | 1.14 (0.38–3.38) | 0.82 | 1.19 (0.40–3.59) | 0.75 | 1.52 (0.48–4.85) | 0.47 | |||
| >37%−87.3% vs 0%−2.24% | 2.06 (0.77–5.49) | 0.15 | 1.81 (0.65–5.06) | 0.26 | 2.32 (0.78–6.88) | 0.13 | |||
| >87.3%−100% vs 0%−2.24% | 2.90 (1.13–7.41) | 0.026 | 3.59 (1.33–9.70) | 0.012 | 4.38 (1.54–12.47) | 0.006 | |||
| Mean SpO2 > 90% (median) vs ≤90% | 185 | 0.43 (0.22–0.82) | 0.010 | 185 | 0.42 (0.21–0.84) | 0.014 | 182 | 0.41 (0.20–0.83) | 0.013 |
AHI = apnea-hypopnea index; BMI = body mass index; DlCO = diffusing capacity of the lungs for carbon monoxide; SpO2 = oxygen saturation; T90 = percentage of recording time with oxygen saturation < 90%.