Fig. 9.

Protein kinase A pathway mutations in cancer. (A) Frequency of specific pathway gene mutation across several tumor and cancer types. Heatmap is colored by mutation frequency (0% to >50%), with darker purple representing higher mutational frequency. All gene mutations from whole genome sequencing data sets are included (COSMIC database) (Tate et al., 2019). (B) Frequency of pathway mutation grouped by gene family across tumor and cancer types. A sample is considered to have a pathway mutation if it harbors at least one mutation in a family gene member.