Figure 4. Integrative multiomics network identifies upstream regulators and mediators of NET formation.

(A) Broad elevation of transcriptomics and proteomics features in NET formation and complement in the severity factor. Pathway connections are from the Kyoto Encyclopedia of Genes and Genomes (KEGG) NET formation pathway. (B) Top cytokines in the severity factor, when bound to their receptors, trigger downstream signaling pathways, including ERK and p38 signaling pathways, and are important in NET formation.