Figure 6. Virus-centered integrative multiomics network of the mortality factor.

(A) Positive association of nasal SARS-CoV-2 viral load and inverse associations of total and SARS-CoV-2–specific antibodies were top features of the mortality factor. (B) JAK/STAT IFN signaling was positively associated with the mortality factor and viral load, and IFN signaling inhibitors were also positively associated with the mortality factor, potentially contributing to the dysregulation of IFN responsiveness and uncontrolled viral load in TG5 despite early ISG elevation. The elevation of apolipoproteins from the plasma proteomics may also have contributed to the heightened STAT activity. Longitudinal trajectories from generalized additive mixed-effects modeling of (C) hallmark IFN-α response genes in the NGX, (D) IFN inhibitors in the NGX, and (E) nasal SARS-CoV-2 viral load determined from RT-qPCR Ct.