Table I.

Previous ultrasound studies and parameters to open BBB.

Reference	Organism	Pressure (MPa)	Frequency (MHz)	Burst rate (Hz)	Burst (ms)	Duration (second)
[21]	Rabbit	1	1.5–1.63	1	100	20
[29]	Mice	0.3	1.5	10	6.7	60
[30]	Rabbit	0.4	0.69	1	10	20
[31]	Primates	0.3	0.5	2	10	120
[24]	Rats	0.2	1	10		60
[32]	Mouse	0.3	1.5	10	20	60
[33]	Rats	0.24	0.558	1	1	120
[34]	Rats	0.55	0.4–1.7	1	10	60
[35]	Mice	0.3	0.5	1	10	120
[36]	Rats	0.62	0.4	1	10	120
[27]	Mice	0.3	0.558	1	10	120
[37]	Mice	0.44	1.5	1	10	120
[38]	Mice	0.67	1.525	10	20	30
[39]	Rats	0.3	0.548	0.5–0.6	10	120
[26]	Rats	0.3	0.590	1	10	120