Fig. 2.

Strategies for regenerating interfacial tissues like the osteochondral interface and tendon-bone enthesis include: leveraging developmental cues to promote resident and progenitor cell remodeling of the interfacial tissues (e.g., Sox9 + /Scx + bi-fated cells, shown in blue, residing between Scx + cells in purple and Sox9 + cells in green); identifying factors that influence formation of nascent ECM in native tissues during remodeling and repair; promoting a regenerative, rather than destructive, inflammatory response; controlling the mechanical environment by increasing or decreasing applied loads (e.g., from skeletal muscle); and understanding and controlling interfacial cell metabolism and physiological response and sensitivity to their environment, such as hypoxia