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. 2024 Mar 11;32(5):576–583. doi: 10.1038/s41431-024-01581-3

Fig. 3. Rare and common variant additivity in ID cases.

Fig. 3

A Comparison of logistic regression models predicting intellectual disability status, where the model with the lowest ΔAICc or ΔBIC is the model that best explains the data. Covariates Only: sex and first ten principal components, PGS Only: cognitive performance PGS and covariates, Rare Variants Only: LOF and damaging missense carrier status and covariates, Rare Variants + PGS: LOF and damaging missense carrier status, cognitive performance PGS, and covariates. B Logistic regression comparing ID cases to population controls, including both LOF or missense MPC > 2 variant carrier status, polygenic score, and an interaction term between rare variant carrier status and polygenic score in the model. CP cognitive performance, *indicates Bonferroni-adjusted p < 0.05.