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. 2024 Apr 30;15:3610. doi: 10.1038/s41467-024-47300-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Peri-event time plots and heat maps of nNOS neurons to male urine (a, b), female urine (c, d), amyl acetate (e, f) or water (g, h) in ovariectomized females that were primed with estradiol and progesterone (OVX + E2 + P4). Peri-event time histogram of nNOS activation following exposure to male urine (i) or female urine (k) in ovariectomized females that were treated with an estradiol implant (OVX + E2). Heat map of nNOS activation during exposure to male urine (j) or female urine (l) in ovariectomized females with and estradiol implant (OVX + E2). Peri-event time histograms and heat maps of nNOS activation in response to male (m, n) or female (o, p) urine in ovariectomized subjects following removal of the estradiol implant and a washout period of two weeks. q Comparison of peak delta F/F of the VMHvl nNOS neurons in response to different olfactory cues. RM one-way ANOVA, followed my Bonferroni multiple comparisons test: F(2.016, 10.08) = 24, p = 0.0001. *p = 0.0412; **p = 0.0061. r Comparison of nNOS activation in response to male urine under different hormonal conditions. RM one-way ANOVA followed by Bonferroni’s post hoc test: F(1.838, 9.188) = 23.0, p = 0.0003. **p = 0.0082 and p = 0.0044 for OVX + E2 + P4 vs OVX + E2 or OVX, respectively. s Activation of nNOS neurons in response to female urine under different hormonal conditions. RM one-way ANOVA: F(1.129, 5.644) = 1.369, p = 0.296. OVX (ovariectomized); E2 (estradiol); P4 (progesterone); AA (amyl acetate); MUrine (male urine); FUrine (female urine). All subjects (n = 6) used in this experiment were sexually experienced. Data are presented as mean ± SEM. Adjustments were made whenever multiple comparisons test is used. Source data are provided as a Source Data file.