Table 3.
Univariate and multivariate analysis of response to CARTr for peripheral BCR
No. of participants = 40 | Univariate analysis |
Multivariate analysis |
||||
---|---|---|---|---|---|---|
OR | 95% CI | P value | OR | 95% CI | P value | |
Prior HSCT (n = 15) | 1.859 | 0.50-6.94 | .356 | 5.175 | 0.83-32.31 | .079 |
BCR ≤3 mo after CARTi (n = 22) | 0.898 | 0.25-3.25 | .870 | 0.996 | 0.20-4.90 | .996 |
CART product | ||||||
Investigational CTL019 (n = 17) | REF | REF | ||||
HuCART19 (n = 14) | 2.400 | 0.55-10.53 | .246 | 1.313 | 0.12-14.28 | .823 |
Commercial tisagenlecleucel (n = 9) | 1.200 | 0.21-6.80 | .837 | 0.344 | 0.04-3.00 | .334 |
Previously treated with a different CART product (n = 7) | 1.313 | 0.25-6.88 | .748 | 0.444 | 0.04-5.10 | .513 |
Lymphodepletion prior to CARTr (n = 28) | 11.000 | 1.25-97.02 | .031 | 33.570 | 2.07-543.24 | .013 |
REF, reference.