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. 2024 Apr 26;103:105132. doi: 10.1016/j.ebiom.2024.105132

Fig. 3.

Fig. 3

Impact of IL-6 inhibition by sgp130Fc in cytokines/chemokines levels in serum and lung tissues from SARS-CoV-2 infected mice. a) Serum levels of the indicated proteins quantified by multiplex platform in each experimental group. b) mRNA expression of the indicated cytokines and chemokines in lung tissue measured by qPCR. Control is set to 1 for each experiment and data is presented as fold-change vs control (mean and 95% CI). SARS-CoV-2 + vehicle 15 dpi (n = 8); SARS-CoV-2 + sgp130Fc 15 dpi (n = 12). SARS-CoV-2 + vehicle <15 dpi (n = 9); SARS-CoV-2 + sgp130Fc < 15 dpi (n = 6). Data are combined from two independent experiments. Statistics were calculated by Kruskal–Wallis test with Mann–Whitney U-test. p values are indicated in the graphs. dpi: days post infection. < 15 dpi: dead/euthanized mice before the end of the experiment. 15 dpi: surviving mice at the end of experiment.