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. 2024 Apr 26;103:105132. doi: 10.1016/j.ebiom.2024.105132

Fig. 5.

Fig. 5

STAT3 target genes expression in lung tissue from sgp130Fc-treated SARS-CoV-2 infected mice. a) mRNA expression of Stat3, Lrg1, Saa1 and Socs3 in lungs quantified by qPCR. Control is set to 1 for each experiment and data presented as fold-change vs control. b) Immunohistochemistry of P (Tyr705)-STAT3 in lung samples. Scale bars: 200 X (100 μm). Data are presented as % of positive cells. SARS-CoV-2 + vehicle 15 dpi (n = 8); SARS-CoV-2 + sgp130Fc 15 dpi (n = 12). SARS-CoV-2 + vehicle <15 dpi (n = 9); SARS-CoV-2 + sgp130Fc < 15 dpi (n = 6). Data are combined from two independent experiments. All graphs show mean and 95% CI. Statistics were calculated by Kruskal–Wallis test with Mann–Whitney U-test (a), and ANOVA with Student's t-test (b). p values are indicated in the graphs. dpi: days post infection. < 15 dpi: dead/euthanized mice before the end of the experiment. 15 dpi: surviving mice at the end of experiment.