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Graphical abstract: IL-6 trans-signalling in SARS-CoV-2 infection on lung microvascular endothelial cells and therapeutic inhibition of IL-6 trans-signalling. Increased levels of IL-6:sIL-6R complexes observed in SARS-CoV2-infected mice induce endothelial cell dysfunction, widespread endothelial damage, coagulopathy and vascular leakage. Therapeutic IL-6 trans-signalling blockade by sgp130Fc exerts anti-inflammatory and anti-coagulant properties and recovers vascular integrity.
