Fig. 1. LS-like heritability and MMR protein expression.

A Pedigrees of families 1 and 2. Cancer type and decade of onset as follows: Colorectal cancer (CRC), prostate cancer (PrCa) and endometrial cancer (EC). Pedigrees have been modified for patient confidentiality. Arrows indicate index-patients selected for Bionano OGM. B Immunohistochemistry of patient endometrial tumour biopsy. Immunohistochemical staining of endometrial tumour tissue sections with antibodies against the four MMR proteins (brown staining) showed missing protein expression of MSH2 and MSH6, while normal expression was obtained for MLH1 and PMS2. Slides were co-stained with hematoxylin (blue) to show cell nuclei. Sections were endometrial tumour tissue from the individual marked with an asterisk in Family 2.