Table 2.
Odds ratios (OR) between quartile concentrations of maternal blood metals and child history of KD.
| Quartile of metal level (ng/g) | KD cases (N = 316) | Non-KD cases (N = 85,062) | Crude model | Adjusted modela | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | p value | Adjusted OR (95% CI) | p value | |||
| Hg | ||||||
| Q1 (< 2.56) | 73 | 21,273 | 1.00 (referent) | 1.0 (referent) | ||
| Q2 (2.57–3.65) | 87 | 21,407 | 1.18 (0.86–1.61) | 0.287 | 1.13 (0.71–1.80) | 0.599 |
| Q3 (3.66–5.20) | 74 | 21,123 | 1.02 (0.73–1.41) | 0.900 | 1.21 (0.77–1.93) | 0.397 |
| Q4 (> 5.21) | 82 | 21,259 | 1.12 (0.81–1.54) | 0.468 | 1.29 (0.82–2.03) | 0.263 |
| P for trend = 0.677 | P for trend = 0.373 | |||||
| Cd | ||||||
| Q1 (< 0.495) | 71 | 21,367 | 1.00 (referent) | 1.0 (referent) | ||
| Q2 (0.496–0.660) | 80 | 21,204 | 1.13 (0.82–1.56) | 0.437 | 0.93 (0.59–1.49) | 0.785 |
| Q3 (0.661–0.899) | 88 | 21,240 | 1.24 (0.91–1.70) | 0.167 | 1.33 (0.87–2.04) | 0.181 |
| Q4 (> 0.900) | 77 | 21,251 | 1.09 (0.78–1.50) | 0.599 | 0.99 (0.63–1.58) | 0.999 |
| P for trend = 0.575 | P for trend = 0.258 | |||||
| Pb | ||||||
| Q1 (< 4.69) | 75 | 21,336 | 1.00 (referent) | 1.0 (referent) | ||
| Q2 (4.70–5.84) | 92 | 21,336 | 1.22 (0.90–1.66) | 0.190 | 1.29 (0.85–1.96) | 0.223 |
| Q3 (5.85–7.31) | 83 | 21,130 | 1.11 (0.81–1.52) | 0.487 | 0.90 (0.57–1.42) | 0.667 |
| Q4 (> 7.31) | 66 | 21,260 | 0.88 (0.63–1.23) | 0.462 | 0.84 (0.52–1.34) | 0.468 |
| P for trend = 0.197 | P for trend = 0.201 | |||||
| Se | ||||||
| Q1 (< 156) | 69 | 21,341 | 1.00 (referent) | 1.0 (referent) | ||
| Q2 (157–168) | 83 | 21,714 | 1.18 (0.85–1.62) | 0.305 | 1.91 (1.21–3.02) | 0.005 |
| Q3 (169–182) | 87 | 21,879 | 1.22 (0.89–1.68) | 0.200 | 1.36 (0.84–2.21) | 0.206 |
| Q4 (> 183) | 77 | 20,128 | 1.18 (0.85–1.63) | 0.311 | 1.17 (0.70–1.94) | 0.542 |
| P for trend = 0.590 | P for trend = 0.056 | |||||
| Mn | ||||||
| Q1 (< 12.6) | 75 | 21,656 | 1.00 (referent) | 1.0 (referent) | ||
| Q2 (12.6–15.3) | 89 | 21,053 | 1.22 (0.89–1.66) | 0.204 | 1.01 (0.66–1.54) | 0.935 |
| Q3 (15.4–18.6) | 79 | 21,290 | 1.07 (0.78–1.47) | 0.669 | 0.90 (0.59–1.39) | 0.661 |
| Q4 (> 18.7) | 73 | 21,063 | 1.00 (0.72–1.38) | 0.996 | 0.70 (0.44–1.11) | 0.138 |
| P for trend = 0.541 | P for trend = 0.270 | |||||
aAdjusted with Covariates, presence or absence of siblings, infant feeding, mother's history of use of medications during pregnancy, mother's history of allergy, child's history of common cold, child's history of gastroenteritis, child's history of allergy, and socioeconomic factors.