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. 2024 Apr 17;12:1378302. doi: 10.3389/fcell.2024.1378302

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Copyright © 2024 Gou, Li, Liu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functions of CAF-derived exosomal miRNA in promoting tumorigenesis and cancer development. TME comprises various cell types, including stromal cells, immune cells, tumor cells, and so on. All these cells were enveloped in ECM (Fang et al., 2023). CAFs, as an important component of TME, can participate in tumor regulation by secreting exosomal miRNAs (Wang J. W. et al., 2019). These miRNAs can take part in immune modulation (Zhao et al., 2022), tumor growth (Shi L. et al., 2022), migration and invasion (Chen B. et al., 2021), EMT (Zhang Y. et al., 2022), and treatment resistance (Fang et al., 2019) (ECM: extracellular matrix; TME: tumor microenvironment; EMT: epithelial-mesenchymal transition). (By Figdraw).