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. 2024 Apr 17;11:1366259. doi: 10.3389/fmolb.2024.1366259

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Copyright © 2024 Chen, Lu, Whitney, Li, Robson, Blakely, Chi, Crowley and Privratsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-1R1 in CD11c⁺ cells decreases expression of Il1b and Il1rn. Myel WT and Myel KO mice were subjected to sham or ischemia-reperfusion surgery for 6 h or 24 h. Kidneys were harvested and mRNA levels of (A) Il1b (B) Tnf and (C) Il6. (D) UMAP plot of cell clusters from scRNAseq analysis of wildtype mouse kidneys in control and ischemic kidneys. Circle denotes myeloid/macro cluster. (E) Feature plots showing Il1b expression. (F) Feature plots showing Il1rn expression. Note major expression of both Il1b and Il1rn occurs in myeloid cell clusters. (G) RT-PCR of anti-inflammatory cytokine Il1rn mRNA levels in kidneys from Myel WT and Myel KO mice after sham, 6-h or 24-h I/R surgery. Dots represent individual samples from each group. Statistical analysis performed by two-way ANOVA with Sidak test (n = 3 for sham groups; n = 8-10 for 6-h groups; n = four to six for 24-h groups; *p < 0.05).