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. 2024 Apr 17;11:1366259. doi: 10.3389/fmolb.2024.1366259

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Copyright © 2024 Chen, Lu, Whitney, Li, Robson, Blakely, Chi, Crowley and Privratsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of working model. The IL-1R1 receptor on CD11c⁺ cells serves as a negative feedback regulator to constrain renal tubular injury by producing anti-inflammatory cytokine IL-1ra during ischemic AKI (Created with Biorender.com).