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. 2024 Feb 16;30(9):1916–1933. doi: 10.1158/1078-0432.CCR-23-3433

Figure 7.

Figure 7. Ex vivo isolated CD8 T cells from mice treated with fenofibrate had decreased glycolytic activity. A, Heavy glucose labeling of ex vivo CD8 T cells from mice on the control diet with HRT alone (gray) or HRT with FF (blue), and mice on the high OAD treated with HRT and FF (green). Mice treated with fenofibrate results in decreased glycolytic flux, which was further decreased by the addition of OA. B, Correlative serum glucose 6-phosphate from HRT alone mice (gray), HRT with FF mice (blue), and mice on the OAD treated with HRT and FF (green). One-way ANOVA with multiple comparisons testing (uncorrected Fisher LSD) was used to determine P values (P values greater than 0.25 not shown).

Ex vivo isolated CD8 T cells from mice treated with fenofibrate had decreased glycolytic activity. A, Heavy glucose labeling of ex vivo CD8 T cells from mice on the control diet with HRT alone (gray) or HRT with FF (blue), and mice on the high OAD treated with HRT and FF (green). Mice treated with fenofibrate results in decreased glycolytic flux, which was further decreased by the addition of OA. B, Correlative serum glucose 6-phosphate from HRT alone mice (gray), HRT with FF mice (blue), and mice on the OAD treated with HRT and FF (green). One-way ANOVA with multiple comparisons testing (uncorrected Fisher LSD) was used to determine P values (P values greater than 0.25 not shown).