Fig. 3:

Example directed acyclic graph for the genetic interaction study. Individual gene knockouts $\delta$ s are the top of the graph, pair knockouts $\tau$ are in the middle, and triplet knockouts $ϵ$ are the leaves. Each node corresponds to an experiment conducted independently and has an independent $p$-value. If any set of genes potentially contributes to synthetic lethality, the null hypothesis at that node is rejected; all subsets must implicitly be rejected as well.