Table 3.
Multivariate analysis for CIR, NRM, RFS, and OS in patients with non-DTA genes
| Variables | n | CIR | NRM | RFS | OS | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | ||
| ddPCR MRD | |||||||||
| Negative | 98 | 1.00[Reference] | 1.00[Reference] | 1.00[Reference] | |||||
| Positive | 52 | 4.02(1.80–8.96) | < 0.001 | 2.92(1.51–5.68) | 0.002 | 3.12(1.36–7.15) | 0.007 | ||
| Remission status at time of HSCT | 0.052 | 0.366 | |||||||
| CR1 | 102 | 1.00[Reference] | 1.00[Reference] | 1.00[Reference] | 1.00[Reference] | ||||
| ≥CR2 | 26 | 2.44(0.93–6.40) | 0.071 | 2.41(0.27–21.30) | 0.430 | 2.28(1.00-5.23) | 0.051 | 1.30(0.42–4.08) | 0.652 |
| No CR | 22 | 1.52(0.58–3.98) | 0.390 | 5.16(0.67-40.00) | 0.120 | 2.27(1.03–5.01) | 0.043 | 1.97(0.77–5.04) | 0.157 |
| DRI-R | |||||||||
| Low/Intermediate | 92 | 1.00[Reference] | 1.00[Reference] | 1.00[Reference] | 1.00[Reference] | ||||
| High/Very high | 58 | 3.39(1.41–8.14) | 0.006 | 5.78(0.68–49.30) | 0.110 | 4.16(1.86–9.34) | 0.001 | 4.00(1.44–11.13) | 0.008 |
Abbreviations ddPCR, droplet digital PCR; MRD, measurable residual disease; CIR, cumulative incidence of relapse; NRM, non-relapse mortality; RFS, relapse-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; CR, complete remission; CR1, first complete remission; CR2, second complete remission; DRI-R, refined disease risk index