Table 3.

KEGG pathway analysis of DEGs in ipsilateral hippocampi of striatal 6-OHDA-lesioned rats.

Pathway	Fold enrichment	Enrichment FDR	Number of genes	Pathway genes
Neuroactive ligand–receptor interaction	3.69	6.15 × 10−14	52	357
Calcium signaling pathway	3.28	4.22 × 10−7	32	233
cAMP signaling pathway	2.61	1.69 × 10−3	23	211
Axon guidance	2.79	1.69 × 10−3	21	178
Notch signaling pathway	3.79	1.75 × 10−2	9	57
ECM–receptor interaction	3.31	1.75 × 10−2	11	82
Aldosterone synthesis and secretion	3.12	1.75 × 10−2	12	93
Pathways in cancer	1.77	1.75 × 10−2	38	519
Cholinergic synapse	2.76	2.45 × 10−2	13	112
Serotonergic synapse	2.64	3.36 × 10−2	13	118
PI3K–Akt signaling pathway	1.84	5.50 × 10−2	25	336

Abbreviations: Akt, Ak strain transforming; cAMP, cyclic adenosine monophosphate; ECM, extracellular matrix; FDR, false discovery rate; KEGG, Kyoto Encyclopedia of Genes and Genomes; PI3 K, Phosphatidylinositol-3-kinase.