Table 5.
Metaregression analyses to explore potential causes of heterogeneity among included studies
| Factor | Outcome | Effect of factor on outcome | Adjusted R2 (%) |
|---|---|---|---|
| Participants with past use of psychedelics (%) | Change in depression scores | Significant (P=0.002)—each percentage point increase in past psychedelic use was associated with an increase of 4.2 points in depression score change | 38.9 |
| Participants with past use of psychedelics (%) | Response rate | Significant (P=0.006)—each percentage increase point increase in past psychedelic use was associated with an increase of 4.4 points in response rates | 93.8 |
| Participants with previous use of psychedelics (%) | Remission rate | Non-significant (P=0.15) | NA |
| Female participants (%) | Change in depression scores | Non-significant (P=0.41) | NA |
| Female participants (%) | Response rate | Non-significant (P=0.71) | NA |
| Female participants (%) | Remission rate | Non-significant (P=0.78) | NA |
| Average participant’s age | Change in depression scores | Significant (P<0.001)—each year increase in age was associated with a 0.16 increase in depression score change | 48.5 |
| Average participant’s age | Response rate | Non-significant (P=0.12) | NA |
| Average participant’s age | Remission rate | Non-significant (P=0.78) | NA |
NA=not applicable.