Table 1. The level of the investigated biomarkers in serum and CSF.

NA: not applicable; sCRP – C reactive protein in serum; sNLR – Neutrophil-to-lymphocyte ratio in serum; cNFs – Neurofilaments in cerebrospinal fluid; GDF15- Growth differentiation factor 15 in serum; !significant MS group regard to healthy control; *significant MS group regard to group with non-inflammatory diseases; ? significant healthy control group with regard to the group with non-inflammatory diseases

	MS group<br>(n=60)	Group with non-inflammatory<br>diseases of the CNS (n=30)	Healthy control group<br>(n=30)	p-value
sCRP	0.80 (0.52–1.00)	6.90 (1.31–18.53)	1.60 (1.00–2.50)	*0.000
sNLR	2.12 (1.76–2.66)	2.23 (1.57–3.62)	1.24 (0.97–1.46)	!?0.000
cNFs	0.13 (0.02–0.18)	0.15 (0.11–0.21)	NA	0.830
sGDF15	143 (122–178)!	300 (210–368)	NA	0.000