Figure 2.

FMT recipient factors at baseline are associated with the differences in fecal microbiota changes in diversity between responders and non-responders in HOMA-IR.

(a) Microbial diversity is associated with improvement in HOMA-IR in patients receiving FMT with fiber supplementation. Analyzed using repeated measures linear mixed model regression after adjusting for donor selection. (b) Comparison of shifts in fecal alpha-diversity (Δ week 6 - baseline) between responders and non-responders, as defined according to changes in HOMA-IR from baseline to week 6 (decreased vs. increased). Statistical comparisons between groups were by ANCOVA adjusted for donor selection. (c) Scatter plots show recipient parameters that predict the changes in microbial diversity after FMT using baseline intakes of calorie-adjusted macronutrients and baseline clinical measurements including anthropometric measurements, immune cytokines, metabolic makers, and fecal bile acids (15 compounds), as well as biomarkers of host-microbiota interactions. Analyzed using repeated measures linear mixed model regression after adjusting for donor selection. LDL, low-density lipoprotein cholesterol; TMCA, tauro-muricholic acid.