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. 2024 Apr 29;16(1):2345134. doi: 10.1080/19490976.2024.2345134

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — FMT recipient baseline factors predict donor-specific ASVs engraftment.

(a) Comparison of the donor-specific ASVs fraction retained in the FMT-recipients between responders and non-responders over the 12 weeks. Line charts compare the ratio of FMT recipients who retained donor-specific ASVs in total number of the recipients (engraftment rate) among responders vs. non-responders. ASVs that had a significantly higher engraftment rate in the responders relative to the non-responders were selected (p < .05). Statistical analysis was performed by repeated measures ANOVA models for assessing the main factor effect. Comparisons were made between the two groups at each time point by t-test with Welch correction. Data are reported as mean ± SEM [+p < .1, *p < .05, **p < .01]. ASV26: Bacteroides fragilis; ASV44: Faecalibacillus intestinalis; ASV48: Bacteroides cellulosilyticus; ASV74: Lachnoclostridium spp.; ASV84: Alistipes finegoldii; ASV93: Alistipes shahii; ASV103: Roseburia spp.; ASV127: Marseillibacter massiliensis; ASV140: Christensenellaceae spp. ASV, amplicon sequence variant. (b) Weighted metric multidimensional scaling based on Bray-Curtis dissimilarity and environmental fitting test analysis (envfit) displaying top 10 recipient baseline factors explaining donor-specific ASVs distribution variation between responders and non-responders at week 6. (c) The figure C evaluated contribution degrees of baseline factors affecting the donor-specific ASVs community in the FMT recipients (measured using coefficient of determination (R2)). And the significant association was tested using permutation test (n = 999) in the vegan package [*p < .05, **p < .01].