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Major genes involved in iris development. Schematic overview of the developing optic cup (8 week old human embryo). Iris development relies on interactions between the periphery of optic cup (OC) or ciliary margin zone (neuroectoderm) and the periocular mesenchyme (POM), which receives contributions from the neural crest (NC) and mesoderm. Main transcription factors (TF) specifically expressed in the optic periphery cup and POM are represented.
