Table 1.
Characteristics of patients with mixed CMBs, D-CMBs, and P-CAA
| Mixed CMBs (n = 53) | D-CMBs (n = 35) | p | P-CAA (n = 89) | p | |
|---|---|---|---|---|---|
| Age, y, mean±SD | 77.0±8.1 | 72.8±10.5 | 0.040∗ | 78.7±6.8 | 0.165 |
| Male, n (%) | 21 (39.6) | 23 (65.7) | 0.017∗ | 40 (44.9) | 0.538 |
| MMSE, median (IQR) | 24 (19–26) | 25 (22–27) | 0.036∗ | 23 (19–28) | 0.222 |
| Hypertension, n (%) | 36 (67.9) | 22 (62.9) | 0.624 | 51 (57.3) | 0.209 |
| Diabetes mellitus, n (%) | 9 (17.0) | 8 (22.9) | 0.494 | 20 (22.5) | 0.432 |
| Dyslipidemia, n (%) | 22 (41.5) | 11 (31.4) | 0.339 | 23 (25.8) | 0.052 |
| Smoking, n (%) | 14 (26.4) | 11 (31.4) | 0.610 | 19 (21.3) | 0.489 |
| HA-SVD-Score, median (IQR) | |||||
| Lacune | 1 (0–1) | 0 (0–1) | 0.063 | 0 (0–1) | 0.003∗ |
| CMBs | 1 (1–1) | 1 (1–1) | 1 | 1 (1–1) | 1 |
| BG-PVS | 1 (1–1) | 0 (0–1) | <0.001∗ | 0 (0–1) | <0.001∗ |
| WMH | 1 (0–1) | 0 (0–1) | <0.001∗ | 1 (0–1) | 0.185 |
| Total | 3 (3–4) | 2 (1–3) | <0.001∗ | 2 (1–3) | <0.001∗ |
| CAA-SVD-Score, median (IQR) | |||||
| Lobar CMBs | 2 (1–2) | 0 (0–0) | <0.001∗ | 1 (1–2) | 0.376 |
| cSS | 0 (0–0) | 0 (0–0) | 0.098 | 0 (0–0) | 0.303 |
| CSO-PVS | 1 (0–1) | 0 (0–1) | 0.320 | 1 (1–1) | <0.001∗ |
| WMH | 1 (0–1) | 0 (0–1) | <0.001∗ | 1 (0–1) | 0.185 |
| Total | 3 (2–4) | 0 (0–1) | <0.001∗ | 3 (2–4) | 0.396 |
BG, basal ganglia; CMB, cerebral microbleed; CSO, centrum semiovale; cSS, cortical superficial siderosis; D-CMBs, deep and/or infratentorial cerebral microbleeds; HA, hypertensive arteriopathy; IQR, interquartile range; MMSE, Mini-Mental State Examination; P-CAA, probable cerebral amyloid angiopathy; PVS, perivascular space; SD, standard deviation; SVD, small vessel disease; WMH, white matter hyperintensity.The p values reported in the column next to D-CMBs indicate comparisons between the mixed CMBs and D-CMBs groups. The p values reported in the column next to P-CAA indicate comparisons between the mixed CMBs and P-CAA groups.
∗
p < 0.05.