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. 2024 May 1;12:RP91883. doi: 10.7554/eLife.91883

Figure 4. Alteration of transcription profiles in Bmpr1a-deficient chondrocytes.

(A) Heatmaps of the top 500 genes expressed in the distal part of the auricle of the Prrx1CreERT; Bmpr1af/f and age- and gender-matched control mice. n=3. (B) KEGG analysis results of the pathways affected by Bmpr1a ablation. (C) Gene Ontology (GO) analysis results of the modules affected by Bmpr1a ablation.

Figure 4.

Figure 4—figure supplement 1. Expression of extracellular matrix (ECM) and protein trafficking-related genes in the auricle of control and Bmpr1a-deficient mice.

Figure 4—figure supplement 1.

(A) Heatmap of ECM-related genes. (B) FKPM values of Smad1/5/9 genes. (C) Representative immunostaining results for Aggrecan and Col10 in growth plates of the mutant and control mice. Scale bars=20 μm. (D) Heatmap of protein trafficking-related genes. (E) FKPM values of ER stress-related genes. F. FKPM values of Golgi stress-related genes.