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. 2024 May 1;12:RP91883. doi: 10.7554/eLife.91883

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© 2023, Yang, Chu et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 5. — (A) Heatmaps of osteoblast-related genes and chondrocyte-related genes differentially expressed in the Bmpr1a-deficient and control mice. n=3. (B). Immunostaining results for Col1α1 in ear sections of the Bmpr1a-deficient and control mice. Scale bars=20 μm. Arrows: positive signals. (C) Alkaline phosphatase (ALP) activity was greatly increased in the auricle of the Prrx1^CreERT; Bmpr1a^f/f mice compared to the control mice. Scale bars=50 μm. Arrows: positive signals. (D) WB results showed that the expression of the osteoblast marker genes Runx2 and osteocalcin was increased in the mutant samples. Right panel: quantitation data. n=3. Unpaired two-tailed Student’s t-test were applied to evaluate the correlation data in (D), p<0.05 was considered as statistically significant.

Figure 5—source data 1. Original file for the western blot in Figure 5D.

elife-91883-fig5-data1.pdf^{(1.3MB, pdf)}

Figure 5—figure supplement 1. — (A) Heatmaps of osteoblast-related genes and chondrocyte-related genes differentially expressed in the Bmpr1a-deficient and control mice. n=3. (B). Immunostaining results for Col1α1 in ear sections of the Bmpr1a-deficient and control mice. Scale bars=20 μm. Arrows: positive signals. (C) Alkaline phosphatase (ALP) activity was greatly increased in the auricle of the Prrx1^CreERT; Bmpr1a^f/f mice compared to the control mice. Scale bars=50 μm. Arrows: positive signals. (D) WB results showed that the expression of the osteoblast marker genes Runx2 and osteocalcin was increased in the mutant samples. Right panel: quantitation data. n=3. Unpaired two-tailed Student’s t-test were applied to evaluate the correlation data in (D), p<0.05 was considered as statistically significant.

Figure 5—source data 1. Original file for the western blot in Figure 5D.

elife-91883-fig5-data1.pdf^{(1.3MB, pdf)}