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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Cancer Discov. 2024 May 1;14(5):752–765. doi: 10.1158/2159-8290.CD-23-0700

Figure 2. TREX1 Depletion Unleashes an Autocrine Signaling Loop that Amplifies Tumor Cell cGAS-STING Signaling.

Figure 2.

(A-B) Immunoblot (A) or ELISA of human CXCL10 or IFN-β in conditioned-media (B) derived from KL cells transduced with the indicated vectors.

(C-D) Immunoblot (C), ELISA of human CXCL10 or IFN-β in conditioned-media (D) derived from H1944 transduced with the indicated vectors.

(E-F) ELISA of human CXCL10 or IFN-β in conditioned-media (E), or Immunoblot in H1944 with the indicated vectors at 24hr, 72hr, or 120hr (F).

(G) Schematic of STING pathway suppression by TREX1

(H) Immunoblot of the indicated proteins in H1944 cells transduced with the indicated vectors treated with IFN-β at the indicated concentration at 24hr.

(I) Immunoblot of the indicated proteins in H1944 cells transduced with the indicated vectors.

p-values were calculated by unpaired two-tailed Student’s t test (B, D, E), *p<0.05, **p<0.01. ns, not significant.