Fig. 1. Tissue-specific differential gene expression from exercise impacts unique sets of disease processes.

In (a), we provide a general overview of the work described here, from human genetic and transcriptomic data and rats subjected to an Endurance Exercise Training (EET) experimental perturbation to triplets of causally entangled genes, tissues, and traits. In (b), we subset Differentially Expressed (DE) Genes to just those determined to be DE at 8W in a sex-consistent manner, and visualize their distribution and tissue-specific composition across uniquely DE genes (genes DE in only one tissue), pairs (in two tissues), triplets, etc. To check for overlap in these gene sets, we also plot the upper triangle of a Jaccard Similarity matrix. In (c), we present alternative ways to characterize Open Targets associations across these gene sets.