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. 2024 May 2;14:10036. doi: 10.1038/s41598-024-60872-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma Sample Analysis for NAP and Receiver Operation Characteristic (ROC) Curve Analysis (A) The plasma levels of NAP between non-disease and PD cohort.; ROC curve analysis for NAP alone (B) ROC curve analysis for NAP alone and (C) ROC curve analysis for NAP plus three clinical variables (C95% confident interval (CI) using Bootstrapping approach in ROC curve. Statistics was calculated by t-test, statistically significant: ****p < 0.0001.