Table 4.
Laboratory tests of patients with HSV infection compared with those without HSV infection in the lesion group.
| Laboratory tests | All cases(n=42) | HSV+ patients (n=19) | HSV− patients (n=23) | p-value |
|---|---|---|---|---|
| BP180 autoantibody a , U/ml, median (IQR) | 89.0 (41.3–145.7) | 124.0 (43.0–467.0) | 66.3 (39.1–127.3) | 0.120 b |
| Positive of BP230 autoantibody c , n (%) | 15 (35.7) | 5 (26.3) | 10 (43.5) | 0.248 d |
| BP230 autoantibody e , U/ml, median (IQR) | 40.7 (25.7–61.8) | 55.7 (28.6–230.7) | 36.5 (25.4–70.4) | 0.513 b |
| Blood routine test f , n (%) | ||||
| Elevated WBC count | 16 (41.0) | 5 (29.4) | 11 (50.0) | 0.195 d |
| Elevated NE count | 17 (43.6) | 6 (35.3) | 11 (50.0) | 0.358 d |
| Elevated NE percentage | 12 (30.8) | 5 (29.4) | 7 (31.8) | 0.872 d |
| Elevated LC count | 2 (5.1) | 0 (0.0) | 2 (9.1) | 0.495 g |
| Elevated LC percentage | 1 (2.6) | 0 (0.0) | 1 (4.5) | >0.999 g |
| Elevated EO count | 13 (33.3) | 5 (29.4) | 8 (36.4) | 0.648 d |
| Elevated EO percentage | 10 (25.6) | 4 (23.5) | 6 (27.3) | >0.999 g |
| Elevated MO count | 17 (43.6) | 10 (58.8) | 7 (31.8) | 0.092 d |
| Elevated MO percentage | 6 (15.4) | 5 (29.4) | 1 (4.5) | 0.068 g |
| Serum proteins h , g/L, mean (SD) | ||||
| Total protein | 63.5 (9.1) | 63.0 (10.2) | 63.9 (8.0) | 0.800 i |
| Albumin | 35.3 (5.5) | 35.2 (6.1) | 35.5 (5.1) | 0.862 i |
| Globulin | 28.2 (5.6) | 27.9 (6.5) | 28.4 (4.8) | 0.812 i |
| Immunoglobulins | ||||
| IgG j , g/L, mean (SD) | 11.6 (4.0) | 10.9 (3.8) | 12.6 (4.3) | 0.446 i |
| IgA j , g/L, mean (SD) | 2.3 (1.0) | 2.2 (1.2) | 2.4 (0.6) | 0.823 i |
| IgM j , g/L, median (IQR) | 0.6 (0.4–0.9) | 0.6 (0.4–0.8) | 0.6 (0.3–1.3) | 0.864 b |
| IgE k , g/L, median (IQR) | 467.0 (188.0–1977.8) | 367.0 (146.0–1068.3) | 789.5 (189.8–2369.8) | 0.334 b |
IQR, interquartile range; WBC, white blood cell; NE, neutrophil; LC, lymphocyte; EO, eosinophils; MO, monocyte; SD, standard deviation; Ig, immunoglobulin.
The titer of BP180 autoantibody was detected with the conventional BP180NC16A ELISA kits (MBL, Nagoya, Japan) following the manufacturer’s instructions. The threshold value was 9 U/ml.
p-value based on Mann–Whitney U-test.
The titer of BP230 autoantibody was detected with the BP230 ELISA kits (Euroimmun, Lübeck, Germany) following the manufacturer’s instructions. The threshold value was 20 U/ml.
p-value based on Pearson χ2 statistic.
The titer of BP230 autoantibody calculated in this table only includes patients whose BP230 autoantibody was detected positive.
There were 39 patients in total in the lesion group detected blood routine test, among whom 17 were HSV-positive patients and 22 were HSV-negative patients.
p-value based on Fisher’s exact test.
There were 33 patients in total in the lesion group detected serum proteins, among whom 17 were HSV-positive patients and 16 were HSV-negative patients.
p-value based on independent’s t-test.
There were 15 patients in total in the lesion group detected IgG, IgA, and IgM, among whom nine were HSV-positive patients and six were HSV-negative patients.
There were 24 patients in total in lesion group detected IgE, among whom 10 were HSV-positive patients and 14 were HSV-negative patients.