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. 2023 Oct 24;30(5):820–828. doi: 10.1093/ibd/izad238

Figure 2.

Figure 2.

Inflammatory bowel disease patients have a reduced frequency of TcdB-specific T helper type 17 (Th17) cells. A, Analysis of TcdB-specific T cell proportions of Th1 cells (n = 14 healthy control [HC] subjects, n = 11 Crohn’s disease [CD] patients, n = 18 ulcerative colitis [UC] patients), Th2 cells (n = 14 HC, n = 11 CD patients, n = 16 UC patients), and Th17 cells (n = 13 HC subjects, n = 11 CD, n = 16 UC). B, Proportions of integrin β7+ cells within TcdB-specific responses for n = 12 CD and n = 17 UC. C, TcdB-specific CD4+ T cells were analyzed using unbiased clustering analysis (FlowSOM). Two clusters with statistically significant differences between cohorts after individual hierarchical gating analyses are shown on tSNE plots. Proportions of each cluster within TcdB-specific CD4+ T cells are shown for all groups (n = 16 HC subjects, n = 12 CD patients, n = 16 UC patients) and compared with proportions within Pediacel-specific responses. Statistical analysis used Kruskal-Wallis tests, patients receiving vedolizumab are colored pink in all plots.