TABLE 4.
Sensitivity, Specificity, and Predictive Values of Soluble P-Selectin and D-Dimer in Detecting Occult Cancer
| Soluble P-selectin >30 ng/mL, % (95% CI) | Soluble P-selectin >62 ng/mL, % (95% CI) | D-dimer >10,000 µg/L, % (95% CI) | Soluble P-selectin >30 ng/mL and D-dimer >10,000 µg/L, % (95% CI) | Soluble P-selectin >62 ng/mL and D-dimer >10,000 µg/L, % (95% CI) | Platelet count ≥350 × 103/µL, % (95% CI) | |
|---|---|---|---|---|---|---|
| Sensitivity | 82.2 (62.4-94.4) | 52.6 (29.5-74.7) | 47.3 (27.3-68.3) | 47.3 (25.2-70.5) | 42.1 (21.1-66.1) | 26.3 (11.8-48.8) |
| Specificity | 26.3 (16.5-38.9) | 84.2 (71.6-92.1) | 78.9 (66.7-87.5) | 82.4 (69.6-90.8) | 91.2 (79.9-96.7) | 94.7 (85.6-98.2) |
| PPV | 27.6 (17.0-41.1) | 52.6 (29.5-74.7) | 42.8 (22.6-65.6) | 47.3 (25.2-70.5) | 61.5 (32.3-84.9) | 62.5 (30.6-86.3) |
| NPV | 83.3 (57.7-95.5) | 84.2 (71.6-92.1) | 81.8 (68.6-90.5) | 82.4 (69.6-90.8) | 82.5 (70.5-90.6) | 79.4 (68.4-87.3) |
| Patients correctly diagnosed | 40.8 (29.8-52.7) | 76.3 (64.9-85.0) | 71.0 (62.1-82.8) | 73.7 (62.1-82.8) | 78.9 (67.8-87.1) | 77.6 (67.1-85.5) |
| Diagnostic odds ratio |
1.90 (0.48-7.47) | 5.92 (1.88-18.7) | 3.37 (1.12-10.16) | 4.23 (1.4-13.1) | 7.56 (2.0-27.5) | 6.6 (2.8-14.9) |
NPV, negative predictive value; PPV, positive predictive value.