TABLE 2.
Factors associated with lung cancer in surfactant-related gene (SRG) variant carriers
| No lung cancer | Lung cancer | Univariable analysis | Multivariable analysis | |||
| OR (95% CI) | p-value | OR (95% CI) | p-value | |||
| Patients | 79 | 20 | ||||
| Age at diagnosis (years) | 37.5 (28.9–47.9) | 48.70 (42.5–53.3) | 1.04 (1.01–1.08) | 0.029 | 1.02 (0.98–1.07) | 0.31 |
| Male sex | 41 (51.9) | 11 (55) | 1.13 (0.42–3.10) | 0.80 | ND | |
| SRG variant | ||||||
| SFTPC/NKX2-1/ABCA3 | 45 (57.0) | 5 (25) | Reference | Reference | Reference | Reference |
| SFTPA1/SFTPA2 | 34 (43.0) | 15 (75) | 5.24 (1.20–22.8)) | 0.03 | 2.74 (0.45–16.69) | 0.27 |
| Smoking | 10 (12.7) | 15 (75) | 20.7 (6.60–76.2) | <0.001 | 17.5 (5.28–68.6) | <0.0001 |
| Environmental exposure | 6 (7.6) | 2 (10) | 1.35 (0.19–6.45) | 0.72 | ND | |
| ILD | 64 (81.0) | 18 (90) | 2.29 (0.58–15.3) | 0.30 | 3.14 (0.58–26.1) | 0.22 |
| Antifibrotic treatment | 4 (5.1) | 7 (35) | 10.1 (2.68–43.4) | <0.001 | ND# | |
| Lung transplantation | 22 (27.8) | 4 (20) | 0.65 (0.17–2.00) | 0.48 | ND | |
| FVC % pred | 62 (51–77) | 65 (53–84) | 1.01 (0.99–1.04) | 0.31 | 0.98 (0.92–1.03) | 0.39 |
| DLCO % pred | 37 (28–57) | 44 (32–64) | 1.01 (0.98–1.04) | 0.45 | 1.03 (0.97–1.11) | 0.30 |
Data are presented as n, median (interquartile range) or n (%), unless otherwise stated. ILD: interstitial lung disease; FVC: forced viral capacity; DLCO: diffusing capacity of the lung for carbon monoxide; ND: not done (variable not included in the multivariable analysis). #: antifibrotic treatment was not included in the multivariate analysis because this variable is a proxy for ILD. Bold indicates p<0.05.