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. 2024 May 2;63(5):2301232. doi: 10.1183/13993003.01232-2023

FIGURE 7.

FIGURE 7

The genotypes of gasdermin B (GSDMB) correlate with the expression of induced interferon-stimulated genes (ISGs) in airway epithelial cells of individuals with asthma after rhinovirus 16-A (RV) infection from a public dataset (GSE172368). a–d) Expression of GSDMB in healthy and asthmatic airway epithelial cells with different 17q21 genotypes: rs2305480 (a), rs2305479 (b), rs7216389 (c) and rs9303280 (d) without RV infection. e–h) Box plots showing genotypes of GSDMB and single-sample gene set enrichment analysis (ssGSEA) score for ISGs gene signature in asthmatic airway epithelial cells before and after RV infection by different genotypes of rs2305480 (e), rs2305479 (f), rs7216389 (g) and rs9303280 (h). i–l) Heatmap showing the expression of ISGs in RV-infected asthmatic airway epithelial cells with different genotypes in the GSDMB GWAS locus rs2305480 (i), rs2305479 (j), rs7216389 (k) and rs9303280 (l), scaled by each gene. NT: no treatment. *: p<0.05.