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. 2024 Apr 9;5(3):100626. doi: 10.1016/j.xinn.2024.100626

Figure 4.

Figure 4

XRN1 is a target of the histidine and isoleucine metabolic pathway

(A) Difference in enrichment analysis before and after AA treatment.

(B) Reactome analysis before and after AA treatment.

(C and D) Western blot expression analysis of XRN1 protein in tumor and nontumor cells with combined AA treatment.

(E) Cytotoxicity effects of AA treatment on XRN1 knockdown cells and wild-type. AA: histidine and isoleucine; HPNE, hTert-HPNE (nonmalignant pancreas epithelial); XRN1, XRN1 gene knockdown in PANC-1 tumor cells; PANC-1, malignant pancreas epithelial and wild-type for the XRN1. Error bars represent mean ± SEM; n.s., not significant; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.