Figure 5.

Amino acid treatment effectively impairs PDAC tumor growth and extends mice survival

(A) Scheme of the in vivo experimental design. GEM, gemcitabine; AA, histidine and isoleucine.

(B and C) Comparison of tumor volume changes among the AA treatment and other treatment conditions.

(D) Comparison of survival rate among the AA treatment and other treatment conditions.

(E) Representative images of H&E staining on xenograft tumor sections for different treatment conditions.

(F) Comparison of percentage necrosis of the AA treatment and other treatment conditions evaluated using histology image analysis. Xenografts: n = 5 for each treatment group. Tumor section image sizes −1,000 and 100 μm. Error bars represent mean ± SEM; n.s., not significant; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.