Table 3.
Sleep diary outcomes.
| Measure | Treatment | After Placebo Run-In | After 1 Week of Dosing | After 2 Weeks of Dosing | F | P |
|---|---|---|---|---|---|---|
| Sleep quality | CBD | 2.8 (1) | 3.4 (1) | 3 (1) | 8.1(2, 582.5) | <.001* |
| PLA | 2.9 (1.1) | 2.9 (1) | 3.1 (0.9) | |||
| No. of awakenings | CBD | 2.1 (1.9) | 1.5 (1.6) | 1.5 (1.7) | 0.4(2, 569.1) | .69 |
| PLA | 1.7 (1.3) | 1.4 (1.7) | 1.3 (1.3) | |||
| WASO (decimal hours) | CBD | 0.6 (0.5) | 0.5 (0.6) | 0.6 (0.7) | 1.3(2, 544.1) | .27 |
| PLA | 0.6 (0.7) | 0.4 (0.7) | 0.4 (0.6) | |||
| SE (%) | CBD | 86.8 (3.1) | 86.4 (4.2) | 87 (2.7) | 1.5(2, 567.1) | .22 |
| PLA | 87 (3.8) | 85.9 (6) | 85.7 (6.3) | |||
| SOL (decimal hours) | CBD | 0.82 (0.9) | 0.6 (0.7) | 0.6 (0.7) | 0.6(2, 576) | .63 |
| PLA | 0.9 (0.7) | 0.6 (0.8) | 0.5 (0.4) | |||
| TST (decimal hours) | CBD | 7.94 (1.5) | 8 (1.6) | 8 (1.5) | 1.8(2, 566.3) | .17 |
| PLA | 8 (1.5) | 7.8 (1.8) | 7.6 (1.8) |
Weekly sleep diary–derived raw means, standard deviation, and interaction terms are shown. *Statistically significant effect (P < .05). “No. of awakenings” indicates number of awakenings after sleep onset. CBD = cannabidiol treatment group, PLA = placebo treatment group, SE = sleep efficiency, SOL = sleep-onset latency, TST = total sleep time, WASO = wake after sleep onset.