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. 2024 Feb 15;84(9):1443–1459. doi: 10.1158/0008-5472.CAN-23-2268

Figure 8.

Figure 8. Co-occurrence of mutations in β-catenin–related genes observed in AXIN1-mutant HCC and colorectal cancer tumors. From the cBioPortal database, we obtained information from AXIN1-mutant HCC and colorectal cancer (CRC) tumors about APC, CTNNB1, and BRAF mutation status, in addition to colorectal cancer tumor location and MSI-status. A, Identification of oncogenic β-catenin mutations in HCC tumors carrying either truncating (n = 49) or missense (n = 15) AXIN1 mutations. B, Identification of oncogenic β-catenin or inactivating APC mutations in colorectal cancer tumors carrying either truncating (n = 15) or missense (n = 58) AXIN1 mutations. The BRAF mutation (light blue) is the classical BRAF-V600E variant. Gray, microsatellite instability-high colorectal cancer tumors carrying a mismatch repair defect. Colorectal cancer tumor location is defined as being located on left- or right-sided of the splenic flexure. Identity of the specific β-catenin and APC mutations can be found in Supplementary Table S7.

Co-occurrence of mutations in β-catenin–related genes observed in AXIN1-mutant HCC and colorectal cancer tumors. From the cBioPortal database, we obtained information from AXIN1-mutant HCC and colorectal cancer (CRC) tumors about APC, CTNNB1, and BRAF mutation status, in addition to colorectal cancer tumor location and MSI-status. A, Identification of oncogenic β-catenin mutations in HCC tumors carrying either truncating (n = 49) or missense (n = 15) AXIN1 mutations. B, Identification of oncogenic β-catenin or inactivating APC mutations in colorectal cancer tumors carrying either truncating (n = 15) or missense (n = 58) AXIN1 mutations. The BRAF mutation (light blue) is the classical BRAF-V600E variant. Gray, microsatellite instability-high colorectal cancer tumors carrying a mismatch repair defect. Colorectal cancer tumor location is defined as being located on left- or right-sided of the splenic flexure. Identity of the specific β-catenin and APC mutations can be found in Supplementary Table S7.