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. 2024 Feb 12;23(5):733–742. doi: 10.1158/1535-7163.MCT-23-0459

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©2024 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 4. The KEGG pathways in which the significantly different metabolites take part between Cohorts 1 and 2. In Cohort 1, the top 3 enriched KEGG pathways were primary bile acid biosynthesis, African trypanosomiasis, and choline metabolism in cancer (A and B). In Cohort 2, the top 3 enriched KEGG pathways were the citrate cycle (TCA cycle), PPAR signaling pathway, and primary bile acid biosynthesis (C and D). KEGG, Kyoto Encyclopedia of Genes and Genomes. — The KEGG pathways in which the significantly different metabolites take part between Cohorts 1 and 2. In Cohort 1, the top 3 enriched KEGG pathways were primary bile acid biosynthesis, African trypanosomiasis, and choline metabolism in cancer (A and B). In Cohort 2, the top 3 enriched KEGG pathways were the citrate cycle (TCA cycle), PPAR signaling pathway, and primary bile acid biosynthesis (C and D). KEGG, Kyoto Encyclopedia of Genes and Genomes.